About TWYNEO

2 key acne‑fighting treatments, together in 1 convenient combo

See how to apply

Powered by microencapsulation technology

Science and innovation unite two trusted acne fighters in one never-before-seen combo.

Illustration of tretinoin and benzoyl peroxide molecules

2 powerful treatments

Tretinoin and benzoyl peroxide (BPO) are two proven treatments for acne.1 BPO deactivates tretinoin, so they typically cannot be combined.2,3

Illustration of encapsulated tretinoin and benzoyl peroxide

United through innovation

TWYNEO cream uses microencapsulation technology to separate the two treatments into tiny capsules.1 Microencapsulation prevents BPO from deactivating tretinoin while in the bottle.2,3

Illustration of encapsulated tretinoin and benzoyl peroxide reaching the skin after application of TWYNEO cream

1 breakthrough for acne

When applied, the technology gradually releases each treatment onto your skin.2 Patients in clinical trials saw clearer skin at just 12 weeks!1

How to apply

It’s as simple as C-A-M-P

Cleanse

Use a mild cleanser to rinse your face, then pat it dry with a soft towel.

Apply the medication

Lightly massage a pea-sized amount of TWYNEO cream onto each area of your face (forehead, chin, nose, and cheeks). Avoid your eyes, lips, and mouth.1 Let dry. Wash your hands, as TWYNEO cream may stain or bleach fabric.

Moisturize

Use a moisturizer as often as needed to minimize skin dryness and irritation.

Protect

Use sunscreen and wear protective clothing to limit your exposure to sunlight.1 Avoid unprotected exposure to sunlight and sunlamps while using TWYNEO cream.1

Tips

  1. Try to avoid exposure to the sun after applying TWYNEO cream. Take precautions before going outside.
  2. Discard your bottle of TWYNEO cream 60 days after first opening.1
  3. Store your bottle of TWNEYO cream at room temperature (68ºF–77ºF or 20Cº–25ºC).1

Not an actual patient.

Teenage boy with acne smiling to camera

About acne

Let’s face it: The fight against acne is brutal.

There it is again, staring back at you in the mirror. Acne can majorly affect your self-esteem, and ignoring it won’t make it go away—in fact, it may get worse.4

So what causes acne?

Hormones

And we’re not just talking about puberty. Hormonal changes for women can cause breakouts, too.5

Carbs

Ugh, we wish it weren’t so! White bread, bagels, and other foods high in carbs have been shown to contribute to acne.6

Certain medications

Drugs containing corticosteroids, testosterone, or lithium can trigger breakouts, so talk to your doctor about them if acne is a concern.7

Stress

It doesn’t cause acne, but it can make your current acne worse…which might stress you out…which might…you get it.5

Untreated acne can leave a mark

(Both physically and emotionally)

Permanent scarring8

Discoloration9

(usually on those with darker skin tones)

Self-esteem issues10

Breakout-busting tips

Wash your face twice a day

Dermatologists recommend you wash your face when you wake up and before you go to bed. Washing more than that can actually irritate your skin.11

But wash gently!

Wash your skin with a non-soap cleanser. Use your fingers, not a sponge or washcloth, and make sure to avoid scrubbing your skin. You can also use moisturizer to prevent your skin from becoming too dry.11

Be picky about your products

Use skincare products that don’t cause acne. These kinds of products are often labeled as:11

  • Non-comedogenic (won’t clog pores)
  • Non-acnegenic (less likely to cause acne)
  • Oil-free

And don’t pick!

We know it’s tempting, but try not to touch, pick at, or pop your acne.11

You're not alone in the fight against acne

It can be frustrating trying product after product without seeing the results you want. It might even feel like you’re alone in the fight, but it doesn’t have to be that way.

Not actual patients.

Three teenage girls with acne smiling to camera

Ask your dermatologist about TWYNEO cream

It combines two powerful acne medications into one, so you can break through your breakouts and face the world with clearer skin.1

TWYNEO packaging and bottle

References:

  1. TWYNEO (tretinoin and benzoyl peroxide) cream, 0.1%/3% [prescribing information]. Raleigh (NC): Mayne Pharma; revised 2025 Feb.
  2. Del Rosso J, Sugarman J, Green L, Lain T, Levy-Hacham O, Mizrahi R, Stein Gold L. Efficacy and safety of microencapsulated benzoyl peroxide and microencapsulated tretinoin for the treatment of acne vulgaris: results from two phase 3 double-blind, randomized, vehicle-controlled studies. J Am Acad Dermatol. 2023;89(4):719-27. doi: 10.1016/j.jaad.2023.05.093
  3. Erlich M, Arie T, Koifman N, Talmon Y. Structure elucidation of silica-based core-shell microencapsulated drugs for topical applications by cryogenic scanning electron microscopy. J Colloid Interface Sci. 2020;579:778-85.
  4. Layton AM. Optimal management of acne to prevent scarring and psychological sequelae. Am J Clin Dermatol. 2001;2(3):135-41. doi: 10.2165/00128071-200102030-00002
  5. Kim HJ, Kim YH. Exploring acne treatments: from pathophysiological mechanisms to emerging therapies. Int J Mol Sci. 2024;25(10):5302. doi: 10.3390/ijms25105302
  6. Ryguła I, Pikiewicz W, Kaminiów K. Impact of diet and nutrition in patients with acne vulgaris. Nutrients. 2024;16(10):1476. doi: 10.3390/nu16101476
  7. Kazandjieva J, Tsankov N. Drug-induced acne. Clin Dermatol. 2017;35(2):156-62.
  8. Xu W, Sinaki DG, Tang Y, Chen Y, Zhang Y, Zhang Z. Acne-induced pathological scars: pathophysiology and current treatments. Burns Trauma. 2024;12:tkad060. doi: 10.1093/burnst/tkad060
  9. Yin NC, McMichael AJ. Acne in patients with skin of color: practical management. Am J Clin Dermatol. 2014;15(1):7-16. doi: 10.1007/s40257-013-0049-1
  10. Zaenglein AL. Acne vulgaris. N Engl J Med. 2018;379(14):1343-52. doi: 10.1056/NEJMcp1702493
  11. Schachner LA, Alexis AF, Andriessen A, Berson D, Gold M, Goldberg DJ, et al. Insights into acne and the skin barrier: optimizing treatment regimens with ceramide-containing skincare. J Cosmet Dermatol. 2023;22(11):2902-9.

Important Safety Information

Indications and usage: TWYNEO cream is a combination tretinoin (0.1%), a retinoid, and benzoyl peroxide (3%) indicated for the topical treatment of acne vulgaris in adults and and pediatric patients 9 years of age and older.

Contraindications: History of serious hypersensitivity reaction to benzoyl peroxide or any component of TWYNEO.

Warnings and precautions:

  • Hypersensitivity: Severe hypersensitivity reactions, including anaphylaxis and angioedema, have been reported with use of benzoyl peroxide products.
  • Skin irritation: Pain, dryness, exfoliation, erythema, and irritation may occur with use of TWYNEO. Avoid application of TWYNEO to cuts, abrasions, eczematous or sunburned skin.
  • Photosensitivity: Minimize unprotected exposure to sunlight and sunlamps. Use sunscreen and protective clothing when sun exposure cannot be avoided.

Adverse reactions: The most common adverse reactions (incidence ≥1%) are pain, dryness, exfoliation, erythema, dermatitis, pruritus, and irritation (all at the application site).

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.