Unique micro-encapsulation technology

0.1% tretinoin & 3% BPO: Finally in 1 fixed dose1

Science and innovation unite two trusted acne fighters in one never-before-seen combo.

TWYNEO packaging and bottle

The power of microencapsulation

Close-up illustration of encapsulated tretinoin and benzoyl peroxide

Core‑shell structure

Silica shells individually encapsulate 0.1% tretinoin & 3% BPO.1

Illustration of encapsulated tretinoin and benzoyl peroxide

Maintained stability

The shells keep the ingredients separated, protecting tretinoin from oxidation and degradation by BPO.2

Illustration of encapsulated tretinoin and benzoyl peroxide reaching the skin after application of TWYNEO cream

Increased tolerability

When applied, the shells, acting as a barrier between the active ingredients and the skin, gradually release tretinoin & BPO.2

References:

  1. TWYNEO (tretinoin and benzoyl peroxide) cream, 0.1%/3% [prescribing information]. Raleigh (NC): Mayne Pharma; revised 2025 Feb.
  2. Del Rosso J, Sugarman J, Green L, Lain T, Levy-Hacham O, Mizrahi R, Stein Gold L. Efficacy and safety of microencapsulated benzoyl peroxide and microencapsulated tretinoin for the treatment of acne vulgaris: results from two phase 3 double-blind, randomized, vehicle-controlled studies. J Am Acad Dermatol. 2023;89(4):719-27. doi: 10.1016/j.jaad.2023.05.093

Important Safety Information

Indications and usage: TWYNEO cream is a combination tretinoin (0.1%), a retinoid, and benzoyl peroxide (3%) indicated for the topical treatment of acne vulgaris in adults and and pediatric patients 9 years of age and older.

Contraindications: History of serious hypersensitivity reaction to benzoyl peroxide or any component of TWYNEO.

Warnings and precautions:

  • Hypersensitivity: Severe hypersensitivity reactions, including anaphylaxis and angioedema, have been reported with use of benzoyl peroxide products.
  • Skin irritation: Pain, dryness, exfoliation, erythema, and irritation may occur with use of TWYNEO. Avoid application of TWYNEO to cuts, abrasions, eczematous or sunburned skin.
  • Photosensitivity: Minimize unprotected exposure to sunlight and sunlamps. Use sunscreen and protective clothing when sun exposure cannot be avoided.

Adverse reactions: The most common adverse reactions (incidence ≥1%) are pain, dryness, exfoliation, erythema, dermatitis, pruritus, and irritation (all at the application site).

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.