Fight acne fast with the 2‑in‑1 that's never been done
TWYNEO cream provides the rapid efficacy you demand and the tolerability your patients deserve.1,2
Acne's first‑ever 0.1% tretinoin & 3% BPO 2‑in‑11
A once-daily, fixed-dose combination of tretinoin 0.1% and benzoyl peroxide 3%, TWYNEO cream uses microencapsulation technology to separately contain each active ingredient in a single formulation.
In clinical studies, TWYNEO demonstrated significant improvements in acne severity at Week 12 and showed an early peak in adverse local tolerability findings that decreased over time.1
Combination meets innovation
TWYNEO cream uses microencapsulation technology to combine two powerful acne treatments in one convenient formula.
Potent doses for real results
Patients using TWYNEO cream showed significant improvement in both inflammatory and non-inflammatory acne in just 12 weeks.1
Not an actual patient.
Favorable tolerability1
Most reported adverse reactions were mild or moderate in severity.1
Not an actual patient.
Don't let your patients break the bank fighting breakouts
Patients may pay as little as $0* for TWYNEO cream with the Mayne Pharma Patient Savings Card.
References:
- TWYNEO (tretinoin and benzoyl peroxide) cream, 0.1%/3% [prescribing information]. Raleigh (NC): Mayne Pharma; revised 2025 Feb.
- Del Rosso J, Sugarman J, Green L, Lain T, Levy-Hacham O, Mizrahi R, Stein Gold L. Efficacy and safety of microencapsulated benzoyl peroxide and microencapsulated tretinoin for the treatment of acne vulgaris: results from two phase 3 double-blind, randomized, vehicle-controlled studies. J Am Acad Dermatol. 2023;89(4):719-27. doi: 10.1016/j.jaad.2023.05.093
*Certain limitations may apply.
The Patient Savings Card Program (“Program”) is brought to you by Mayne Pharma. The Program is only available for commercially unrestricted or commercially restricted/cash-paying patients at participating pharmacies. Patients who are enrolled in state or federally government-run or government-sponsored healthcare plan with a pharmacy benefit are not eligible to use the Mayne Pharma Patient Savings Card (“Card”). Any claim under the Program must be submitted by participating pharmacies to one of the Administrators of the Program.
The Program is subject to applicable state and federal law and is void where prohibited by law, rule or regulation. In the event a lower cost generic drug that the FDA has designated as a therapeutic equivalent product is available for one of the products covered by the Program, or if the active ingredient of a product is available at a lower cost without a prescription, this offer will become void in California and Massachusetts with respect to the product.
Important Safety Information
Indications and usage: TWYNEO cream is a combination tretinoin (0.1%), a retinoid, and benzoyl peroxide (3%) indicated for the topical treatment of acne vulgaris in adults and and pediatric patients 9 years of age and older.
Contraindications: History of serious hypersensitivity reaction to benzoyl peroxide or any component of TWYNEO.
Warnings and precautions:
- Hypersensitivity: Severe hypersensitivity reactions, including anaphylaxis and angioedema, have been reported with use of benzoyl peroxide products.
- Skin irritation: Pain, dryness, exfoliation, erythema, and irritation may occur with use of TWYNEO. Avoid application of TWYNEO to cuts, abrasions, eczematous or sunburned skin.
- Photosensitivity: Minimize unprotected exposure to sunlight and sunlamps. Use sunscreen and protective clothing when sun exposure cannot be avoided.
Adverse reactions: The most common adverse reactions (incidence ≥1%) are pain, dryness, exfoliation, erythema, dermatitis, pruritus, and irritation (all at the application site).
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.